The etiology of primary biliary cirrhosis (PBC), much like that of other autoimmune diseases, remains enigmatic. In the case of PBC, several candidates have been proposed, including bacteria, chemicals, and retroviruses. The support for a retroviral etiology has led to a pilot therapeutical interventional program. However, there is limited objective data which can be used to support such a thesis. Until reproducible and mechanistically sound data can be offered, we suggest that pharmaceutical trials are unrealistic and should be discouraged.
Apocalypsal versus apocryphal : the role of retroviruses in primary biliary cirrhosis / M.E. Gershwin, C. Selmi. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 99:12(2004 Dec), pp. 2356-2358. [10.1111/j.1572-0241.2004.41157.x]
Apocalypsal versus apocryphal : the role of retroviruses in primary biliary cirrhosis
C. SelmiUltimo
2004
Abstract
The etiology of primary biliary cirrhosis (PBC), much like that of other autoimmune diseases, remains enigmatic. In the case of PBC, several candidates have been proposed, including bacteria, chemicals, and retroviruses. The support for a retroviral etiology has led to a pilot therapeutical interventional program. However, there is limited objective data which can be used to support such a thesis. Until reproducible and mechanistically sound data can be offered, we suggest that pharmaceutical trials are unrealistic and should be discouraged.Pubblicazioni consigliate
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