Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine formation in vivo and a concomitant increase in the activity of tyrosine hydroxylase, measured in vitro with a subsaturating concentration of pteridine cofactor. Activation of tyrosine hydroxylase also occurs when isolated eyes from rats killed in the dark are exposed to a strobe light. Studies of amacrine neurons should provide basic data about the biochemical processing of visual information, as well as the physiological presynaptic regulatory mechanisms of dopamine-containing neurons.

Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurons / P.M. Iuvone, C.L. Galli, C.K. Garrison-Gund, N.H. Neff. - In: SCIENCE. - ISSN 0036-8075. - 202:4370(1978 Nov), pp. 901-902. [10.1126/science.30997]

Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurons

C.L. Galli
Secondo
;
1978

Abstract

Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine formation in vivo and a concomitant increase in the activity of tyrosine hydroxylase, measured in vitro with a subsaturating concentration of pteridine cofactor. Activation of tyrosine hydroxylase also occurs when isolated eyes from rats killed in the dark are exposed to a strobe light. Studies of amacrine neurons should provide basic data about the biochemical processing of visual information, as well as the physiological presynaptic regulatory mechanisms of dopamine-containing neurons.
Settore BIO/14 - Farmacologia
nov-1978
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/220417
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