Thiamphenicol is an analogue of chloramphenicol and is characterised by a broad spectrum of action. In this study, serum and lung levels of thiamphenicol (TAP) were studied in infected guinea pigs after the administration of thiamphenicol glycinate N-acetylcysteinate (TGA). Animals received a single dose of TGA (15 mg/kg, subcutaneously) immediately after intra-tracheal infection with Haemophilus influenzae (about 10(7) CFU/animal). Serum and lung concentrations of TAP were determined at 0, 1, 3, 6, 12 and 24 h after drug administration by means of HPLC. TAP serum levels were elevated at 1 h and remained detectable for 24 h after drug administration. Tissue lung levels were comparable to peak serum concentrations but remained higher and decreased more slowly than serum concentrations.
|Titolo:||Serum and lung levels of thiamphenicol after administration of its glycinate N-acetylcysteinater ester in experimentally infected guinea pigs|
DRAGO, LORENZO (Primo)
DE VECCHI, ELENA (Secondo)
GISMONDO, MARIA RITA (Ultimo)
|Parole Chiave:||thiamphenicol ; glycinate N-acetylcysteinater ester ; infected guinea|
|Data di pubblicazione:||2000|
|Appare nelle tipologie:||01 - Articolo su periodico|