Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein–glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.

Multivalent glycoconjugates as anti-pathogenic agents / A. Bernardi, J. Jiménez Barbero, A. Casnati, C. De Castro, T. Darbre, F. Fieschi, J. Finne, H. Funken, K. Jaeger, M. Lahmann, T.K. Lindhorst, M. Marradi, P. Messner, A. Molinaro, P.V. Murphy, C. Nativi, S. Oscarson, S. Penadés, F. Peri, R.J. Pieters, O. Renaudet, J. Reymond, B. Richichi, J. Rojo, F. Sansone, C. Schäffer, W.B. Turnbull, T. Velasco Torrijos, S. Vidal, S. Vincent, T. Wennekes, H. Zuilhof, A. Imberty. - In: CHEMICAL SOCIETY REVIEWS. - ISSN 0306-0012. - 42:11(2013), pp. 4709-4727. [10.1039/c2cs35408j]

Multivalent glycoconjugates as anti-pathogenic agents

A. Bernardi
Primo
;
2013

Abstract

Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein–glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
fimbriated escherichia-coli; lectin pa-IIL; protein-carbohydrate interactions; pseudomonas-aeruginosa biofilms; DC-sign; bacterial lectin; cholera-toxin; high-affinity; structural basis; glycopeptide dendrimers
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/220169
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