In the complex interplay between organization of the living matter, natural selection and adaptation, mammals have evolved with limited or no re-generative capabilities of the heart after birth. The reasons for this apparent flaw is far from being understood, however, they are closely related to the concept of organization and allocation of resources in a hierarchically structured multi-cellular organism with an evolved system of transport and communication, such as the circulation of blood. In humans this flaw may not have been a problem for thousands of years until, in the twentieth century, the increase in life expectancy has given rise to diseases generally less frequent in the first three or four decades of life. Therefore, the significant increase in morbidity and mortality related to cardiovascular disease, seen mainly in Western countries in the last years, has brought to the foreground the problem of cardiac damage and of its repair. In order to develop new therapies for cardiovascular damage aimed at reawakening and, possibly, expanding the limited re-generative capabilities of the heart is necessary to reconsider the basic concept on adaptation and functional reserve allocation in complex organisms.
Adaptation and Evolution in a Gravitational Environment — A Theoretical Framework for the Limited Re–Generative Post–Natal Time Window of the Heart in Higher Vertebrates / M.M. Ciulla, G.L. Perrucci, F. Magrini - In: Regenerative medicine and tissue engineering / [a cura di] J.A. Andrades. - [s.l] : InTech - Open Access Publisher, 2013. - ISBN 978-953-51-1108-5.
|Titolo:||Adaptation and Evolution in a Gravitational Environment — A Theoretical Framework for the Limited Re–Generative Post–Natal Time Window of the Heart in Higher Vertebrates|
CIULLA, MICHELE MARIO (Primo)
PERRUCCI, GIANLUCA LORENZO (Secondo)
MAGRINI, FABIO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
Settore MED/04 - Patologia Generale
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Settore BIO/09 - Fisiologia
|Data di pubblicazione:||2013|
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|
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