Biofilm resistance to biocides is becoming a global issue with an impact on many fields, including health care, agriculture, the environment, society and industry. Plants offer a virtually inexhaustible and sustainable resource of very interesting classes of biologically active, low-molecular-weight compounds (parvome). In the past, the plant parvomes were screened mainly for their lethal effects, disregarding concentrations and ecologically relevant functions of these molecules in the natural context. Testing sub-lethal concentrations of plant-derived compounds mimicking environmental levels may be critical to reveal mechanisms subtler than the killing activity, e.g. those influencing the multicellular behavior, offering an elegant way to develop novel biocide-free antibiofilm strategies. In a cross-disciplinary fashion, we illustrated recent successes of sub-lethal concentrations of plant-derived compounds, their ecological insight, pro et contra, future directions and impacts, envisioning implications for policy making and resource management.

Plant-derived bioactive compounds at sub-lethal concentrations: towards smart biocide-free antibiofilm strategies / F. Villa, F. Cappitelli. - In: PHYTOCHEMISTRY REVIEWS. - ISSN 1568-7767. - 12:1(2013 Mar), pp. 245-254. [10.1007/s11101-013-9286-4]

Plant-derived bioactive compounds at sub-lethal concentrations: towards smart biocide-free antibiofilm strategies

F. Villa
Primo
;
F. Cappitelli
Ultimo
2013

Abstract

Biofilm resistance to biocides is becoming a global issue with an impact on many fields, including health care, agriculture, the environment, society and industry. Plants offer a virtually inexhaustible and sustainable resource of very interesting classes of biologically active, low-molecular-weight compounds (parvome). In the past, the plant parvomes were screened mainly for their lethal effects, disregarding concentrations and ecologically relevant functions of these molecules in the natural context. Testing sub-lethal concentrations of plant-derived compounds mimicking environmental levels may be critical to reveal mechanisms subtler than the killing activity, e.g. those influencing the multicellular behavior, offering an elegant way to develop novel biocide-free antibiofilm strategies. In a cross-disciplinary fashion, we illustrated recent successes of sub-lethal concentrations of plant-derived compounds, their ecological insight, pro et contra, future directions and impacts, envisioning implications for policy making and resource management.
Biocide-free strategies; Biofilm; Plant-derived compounds; Sub-lethal concentrations
Settore AGR/16 - Microbiologia Agraria
mar-2013
Article (author)
File in questo prodotto:
File Dimensione Formato  
Phytochem Rev_2013_Villa.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 470.75 kB
Formato Adobe PDF
470.75 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Phyt Rev_Villa and Cappitelli 2013-revised.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 215.39 kB
Formato Adobe PDF
215.39 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/219928
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 41
  • ???jsp.display-item.citation.isi??? 40
social impact