The aim of this multicenter GIMEMA study was to correlate autoimmune complications (AIC) in B-cell chronic lymphocytic leukemia (B-CLL) with stage and therapy. Autoimmune hemolytic anemia (129/194 cases) and autoimmune thrombocytopenia (35/194 cases) were typically present in advanced and multi-treated disease. Age over the median, stage C and first and second line therapy were identified as independent risk factors by multivariate analysis. In contrast, non-hematologic AIC (30/194 cases) and the presence of serological markers of autoimmunity were mostly observed in early B-CLL, suggesting different pathogenic mechanisms underlying hematologic and non-hematologic autoimmune phenomena in B-CLL.
|Titolo:||Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia|
|Parole Chiave:||B-CLL ; Autoimmunity ; AIHA ; AITP ; Fludarabine|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
Settore MED/15 - Malattie del Sangue
|Data di pubblicazione:||2006|
|Appare nelle tipologie:||01 - Articolo su periodico|