γ-aminobutyric acid typeB(GABA-B)receptor mediates the inhibitory transmission of γ-aminobutyric acid in the mammalian nervous system, being present in neurons and also in glial cells. Recently the presence of GABA-B has been demonstrated in Schwann cells(SC)suggesting its contribution in regulating the cell fate, maturation,and plasticity. Here, we further support the functional presence of GABA-B receptor in SC plasmamembrane. By confocal microscopy immunofluorescence we provide evidences thatGABA-B localization on the cell elongated processes correlates with the morphological changes occurring in the differentiated SC. In vivo most of the GABA-B receptors seem to be present in non-myelinating SC, which are committed to ensheath the nociceptive fibers. Therefore, we argue thatGABA-B receptors do not control exclusively the in vivo differentiation yielding the myelinating SC, but are also fundamental in regulating the SC plasticity versus the non-myelinating state. Data from the literature and our recent findings corroborate the role of the GABAergic system and GABA-B receptors in the peripheral nervous system, opening new perspectives on the mechanisms controlling the differentiation of SC.

GABA-B receptors in the PNS have a role in Schwann cells differentiation? / P. Procacci, M. Ballabio, L.F. Castelnovo, C. Mantovani, V. Magnaghi. - In: FRONTIERS IN CELLULAR NEUROSCIENCE. - ISSN 1662-5102. - 6(2013), pp. 68.1-68.7.

GABA-B receptors in the PNS have a role in Schwann cells differentiation?

P. Procacci;M. Ballabio;L.F. Castelnovo;V. Magnaghi
2013

Abstract

γ-aminobutyric acid typeB(GABA-B)receptor mediates the inhibitory transmission of γ-aminobutyric acid in the mammalian nervous system, being present in neurons and also in glial cells. Recently the presence of GABA-B has been demonstrated in Schwann cells(SC)suggesting its contribution in regulating the cell fate, maturation,and plasticity. Here, we further support the functional presence of GABA-B receptor in SC plasmamembrane. By confocal microscopy immunofluorescence we provide evidences thatGABA-B localization on the cell elongated processes correlates with the morphological changes occurring in the differentiated SC. In vivo most of the GABA-B receptors seem to be present in non-myelinating SC, which are committed to ensheath the nociceptive fibers. Therefore, we argue thatGABA-B receptors do not control exclusively the in vivo differentiation yielding the myelinating SC, but are also fundamental in regulating the SC plasticity versus the non-myelinating state. Data from the literature and our recent findings corroborate the role of the GABAergic system and GABA-B receptors in the peripheral nervous system, opening new perspectives on the mechanisms controlling the differentiation of SC.
Actin; CAMP; GABA; Myelin; Non-myelinating cells; Peripheral nervous system
Settore MED/13 - Endocrinologia
Settore BIO/17 - Istologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/219564
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