γ-aminobutyric acid typeB(GABA-B)receptor mediates the inhibitory transmission of γ-aminobutyric acid in the mammalian nervous system, being present in neurons and also in glial cells. Recently the presence of GABA-B has been demonstrated in Schwann cells(SC)suggesting its contribution in regulating the cell fate, maturation,and plasticity. Here, we further support the functional presence of GABA-B receptor in SC plasmamembrane. By confocal microscopy immunofluorescence we provide evidences thatGABA-B localization on the cell elongated processes correlates with the morphological changes occurring in the differentiated SC. In vivo most of the GABA-B receptors seem to be present in non-myelinating SC, which are committed to ensheath the nociceptive fibers. Therefore, we argue thatGABA-B receptors do not control exclusively the in vivo differentiation yielding the myelinating SC, but are also fundamental in regulating the SC plasticity versus the non-myelinating state. Data from the literature and our recent findings corroborate the role of the GABAergic system and GABA-B receptors in the peripheral nervous system, opening new perspectives on the mechanisms controlling the differentiation of SC.
|Titolo:||GABA-B receptors in the PNS have a role in Schwann cells differentiation?|
|Parole Chiave:||Actin; CAMP; GABA; Myelin; Non-myelinating cells; Peripheral nervous system|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
Settore BIO/17 - Istologia
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||10.3389/fncel.2012.00068|
|Appare nelle tipologie:||01 - Articolo su periodico|