Platelet contamination in stored plasma may affect coagulation assays, including the endogenous thrombin potential (ETP), which has been proposed for the investigation of hyper- and hypo-coagulability. The current recommendation of filtering plasma before freezing cannot be always met. This study provides evidence that filtering frozen plasma after thawing, prior to testing, may help to eliminate the unwanted effect of residual platelets on the ETP. This may have important implications in future studies, as the ETP could be determined with plasma that have been collected without precautions relating to platelet contamination, as is the case for plasmas collected in epidemiological studies.

Standardisation of the endogenous thrombin potential (ETP) measurement : how to minimise the effect of residual platelets in stored plasma / V. Chantarangkul, M. Clerici, C. Bressi, A. Tripodi. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 124:3(2004 Feb), pp. 355-357.

Standardisation of the endogenous thrombin potential (ETP) measurement : how to minimise the effect of residual platelets in stored plasma

A. Tripodi
2004

Abstract

Platelet contamination in stored plasma may affect coagulation assays, including the endogenous thrombin potential (ETP), which has been proposed for the investigation of hyper- and hypo-coagulability. The current recommendation of filtering plasma before freezing cannot be always met. This study provides evidence that filtering frozen plasma after thawing, prior to testing, may help to eliminate the unwanted effect of residual platelets on the ETP. This may have important implications in future studies, as the ETP could be determined with plasma that have been collected without precautions relating to platelet contamination, as is the case for plasmas collected in epidemiological studies.
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/21955
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