There is an unmet need for proangiogenic therapeutic molecules for the treatment of tissue ischemia in cardiovascular diseases. However, major inducers of angiogenesis such as vascular endothelial growth factor (VEGF/VEGF-A) have side effects that limit their therapeutic utility in vivo, especially at high concentrations. Angiopoietin-1 has been considered to be a blood vessel stabilization factor that can inhibit the intrinsic property of VEGF to promote vessel leakiness. In this study, we have designed and tested the angiogenic properties of chimeric molecules consisting of receptor-binding parts of VEGF and angiopoietin-1. We aimed at combining the activities of both factors into 1 molecule for easy delivery and expression in target tissues.

Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis / A. Anisimov, D. Tvorogov, A. Alitalo, V. Leppänen, Y. An, E. C. Han, F. Orsenigo, E. I. Gaál, T. Holopainen, Y. J. Koh, T. Tammela, P. Korpisalo, S. Keskitalo, M. Jeltsch, S. Ylä-Herttuala, E. Dejana, G. Y. Koh, C. Choi, P. Saharinen, K. Alitalo. - In: CIRCULATION. - ISSN 0009-7322. - 127:4(2013 Jan 29), pp. 424-434. [10.1161/CIRCULATIONAHA.112.127472]

Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis

E. Dejana;
2013

Abstract

There is an unmet need for proangiogenic therapeutic molecules for the treatment of tissue ischemia in cardiovascular diseases. However, major inducers of angiogenesis such as vascular endothelial growth factor (VEGF/VEGF-A) have side effects that limit their therapeutic utility in vivo, especially at high concentrations. Angiopoietin-1 has been considered to be a blood vessel stabilization factor that can inhibit the intrinsic property of VEGF to promote vessel leakiness. In this study, we have designed and tested the angiogenic properties of chimeric molecules consisting of receptor-binding parts of VEGF and angiopoietin-1. We aimed at combining the activities of both factors into 1 molecule for easy delivery and expression in target tissues.
Angiogenesis inducers; Capillary permeability; Gene therapy; Ischemia; Vascular endothelium
Settore MED/04 - Patologia Generale
29-gen-2013
Article (author)
File in questo prodotto:
File Dimensione Formato  
Circulation-2013-Anisimov-424-34.pdf

accesso riservato

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 6.7 MB
Formato Adobe PDF
6.7 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/219513
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 48
  • ???jsp.display-item.citation.isi??? 48
social impact