Life expectancy of thalassemia patients has markedly improved over the last few decades, but patients still suffer from many complications of their congenital chronic disease, and several new complications are now being acknowledged, including thrombosis. The high prevalence of thromboembolic events, especially in thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. This review summarizes current knowledge of the clinical and pathophysiological characteristics of hypercoagulability in thalassemia patients. Strategies to prevent thrombotic events are also discussed.

Hypercoagulability in β-thalassemia : a status quo / M.D. Cappellini, E. Poggiali, A.T. Taher, K.M. Musallam. - In: EXPERT REVIEW OF HEMATOLOGY. - ISSN 1747-4086. - 5:5(2012 Oct), pp. 505-512.

Hypercoagulability in β-thalassemia : a status quo

M.D. Cappellini;E. Poggiali;
2012

Abstract

Life expectancy of thalassemia patients has markedly improved over the last few decades, but patients still suffer from many complications of their congenital chronic disease, and several new complications are now being acknowledged, including thrombosis. The high prevalence of thromboembolic events, especially in thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients. This review summarizes current knowledge of the clinical and pathophysiological characteristics of hypercoagulability in thalassemia patients. Strategies to prevent thrombotic events are also discussed.
coagulopathy; hypercoagulability; thalassemia intermedia; thalassemia major; thrombosis
Settore MED/09 - Medicina Interna
ott-2012
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/219313
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