OBJECTIVE: To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. DESIGN: Retrospective study. SETTING: Academic department and referral center for endometriosis. PATIENT(S): A consecutive series of 516 women who underwent excision of 874 endometriomas. INTERVENTION(S): Histological review by three expert pathologists and immunohistochemical staining for IMP3. MAIN OUTCOME MEASURE(S): Test performance of IMP3 immunohistochemistry versus first-round histology. RESULT(S): The prevalence of atypical endometriosis was 1.7% (95% confidence interval [CI], 0.9%-3.3%) based on the number of women and 1.0% (95% CI, 0.5%-1.9%) based on the number of cysts. Three cases of atypical endometriosis were identified at first-round histological examination. Immunohistochemistry detected seven of the eight cases diagnosed as preneoplastic atypia at second-round histology and one case diagnosed as reactive atypia at second-round histology. The sensitivity of first-round histology was 33.3%, compared with 88.9% of IMP3 immunohistochemistry. CONCLUSION(S): Immunohistochemical staining for IMP3 expression is a simple, inexpensive, and sensitive test that can be used in routine clinical practice as a triage tool to discriminate between cytological/structural atypia and confounding benign conditions

The oncofetal protein IMP3 : a novel biomarker and triage tool for premalignant atypical endometriotic lesions / P. Vercellini, F.M. Cribiù, A. Del Gobbo, M.L. Carcangiu, E. Somigliana, S. Bosari. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 99:7(2013 Jun), pp. 1974-1979. [10.1016/j.fertnstert.2013.02.002]

The oncofetal protein IMP3 : a novel biomarker and triage tool for premalignant atypical endometriotic lesions

P. Vercellini
Primo
;
A. Del Gobbo;E. Somigliana
Penultimo
;
S. Bosari
Ultimo
2013-06

Abstract

OBJECTIVE: To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. DESIGN: Retrospective study. SETTING: Academic department and referral center for endometriosis. PATIENT(S): A consecutive series of 516 women who underwent excision of 874 endometriomas. INTERVENTION(S): Histological review by three expert pathologists and immunohistochemical staining for IMP3. MAIN OUTCOME MEASURE(S): Test performance of IMP3 immunohistochemistry versus first-round histology. RESULT(S): The prevalence of atypical endometriosis was 1.7% (95% confidence interval [CI], 0.9%-3.3%) based on the number of women and 1.0% (95% CI, 0.5%-1.9%) based on the number of cysts. Three cases of atypical endometriosis were identified at first-round histological examination. Immunohistochemistry detected seven of the eight cases diagnosed as preneoplastic atypia at second-round histology and one case diagnosed as reactive atypia at second-round histology. The sensitivity of first-round histology was 33.3%, compared with 88.9% of IMP3 immunohistochemistry. CONCLUSION(S): Immunohistochemical staining for IMP3 expression is a simple, inexpensive, and sensitive test that can be used in routine clinical practice as a triage tool to discriminate between cytological/structural atypia and confounding benign conditions
atypical endometriosis; endometrioma; Endometriosis; IMP3
Settore MED/40 - Ginecologia e Ostetricia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/218007
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