Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis with increased mortality largely attributable to cardiovascular disease. There is extensive evidence that patients with RA experience accelerated atherosclerosis, which is considered as the main responsible of this increased cardiovascular burden. Nowadays atherosclerosis is regarded as an inflammatory condition: hence, the cumulative inflammation of RA, with the abundant synthesis of proinflammatory cytokines, contributes directly to the early formation of the atheromatic plaque. It is therefore reasonable to postulate that, by alleviating inflammation, drugs commonly used in RA treatment may ameliorate the cardiovascular profile of these patients. Here we provide an extensive review of the literature, focusing on the effects of the available anti-rheumatic agents on cardiovascular mortality, and morbidity among RA sufferers.

Potential effect of anti-inflammatory treatment on reducing the cardiovascular risk in rheumatoid arthritis / C. Chighizola, T. Schioppo, F. Ingegnoli, P. L. Meroni. - In: CURRENT VASCULAR PHARMACOLOGY. - ISSN 1570-1611. - 10:5(2012 Sep), pp. 639-646.

Potential effect of anti-inflammatory treatment on reducing the cardiovascular risk in rheumatoid arthritis

C. Chighizola
Primo
;
T. Schioppo
Secondo
;
F. Ingegnoli
Penultimo
;
P. L. Meroni
Ultimo
2012

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis with increased mortality largely attributable to cardiovascular disease. There is extensive evidence that patients with RA experience accelerated atherosclerosis, which is considered as the main responsible of this increased cardiovascular burden. Nowadays atherosclerosis is regarded as an inflammatory condition: hence, the cumulative inflammation of RA, with the abundant synthesis of proinflammatory cytokines, contributes directly to the early formation of the atheromatic plaque. It is therefore reasonable to postulate that, by alleviating inflammation, drugs commonly used in RA treatment may ameliorate the cardiovascular profile of these patients. Here we provide an extensive review of the literature, focusing on the effects of the available anti-rheumatic agents on cardiovascular mortality, and morbidity among RA sufferers.
Plaque, Atherosclerotic; Atherosclerosis; Anti-Inflammatory Agents; Animals; Risk Factors; Humans; Arthritis, Rheumatoid; Cytokines; Cardiovascular Diseases; Antirheumatic Agents; Inflammation
Settore MED/16 - Reumatologia
set-2012
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/217654
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