The Amplitude of Dominant T-Wave Alternans (ADTWA) is a recently introduced index which quantifies the presence of microvolt T Wave Alternans (TWA) on surface ECG recordings. In this paper we investigate the reliability of ADTWA and its robustness against broadband noise. At this regard, we generated synthetic 12-leads ECG recordings through a forward electrophysiological model and we added TWA, at different extent, by modulating the variation of the repolarization times of transmembrane action potentials across even and odd beats. Using a stochastic model, we derived an analytical relationship between the repolarization variation injected into the model and TWA at the surface, thus offering a strategy to evaluate lead sensitivity. In terms of robustness, the results of the simulations show that ADTWA correctly measured the amplitude of synthetic TWA with an average error of 3.3% ± 5.8% in absence of noise. When a 100 μV peak-to-peak broadband noise is present, its effects on estimation errors were kept limited by singular value decomposition on which ADTWA builds.
Amplitude of dominant T-wave alternans assessment on ECGs obtained from a biophysical model / R. Sassi, L.T. Mainardi, S. Cerutti (PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). - In: Engineering in Medicine and Biology Society,EMBC, 2011 Annual International Conference of the IEEE[s.l] : IEEE Press, 2011. - ISBN 978-1-4244-4121-1. - pp. 5872-5875 (( Intervento presentato al 33. convegno Annual International Conference of the IEEE, Engineering in Medicine and Biology Society (EMBC) tenutosi a Boston nel 2011.
|Titolo:||Amplitude of dominant T-wave alternans assessment on ECGs obtained from a biophysical model|
|Parole Chiave:||Approximation methods; Electric potential; Electrocardiography; Equations; Lead; Mathematical model; Noise|
|Settore Scientifico Disciplinare:||Settore ING-INF/06 - Bioingegneria Elettronica e Informatica|
Settore INF/01 - Informatica
|Data di pubblicazione:||2011|
|Enti collegati al convegno:||Institute of Electrical and Electronics Engineers|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1109/IEMBS.2011.6091452|
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|