Open loop linear parametric modeling approach was applied to describe the variability of the ventricular depolarization and repolarization duration (i.e. the QT interval from the ECG). Several model structures were compared. The model maximizing the goodness of fit describes the QT interval as a linear combination of its own past values plus two exogenous influences (i.e. heart period interval and respiration) and a colored noise. When this model was applied to a protocol imposing a progressive increase of the sympathetic activity and modulation (i.e. the graded head-up tilt), the goodness of fit gradually decreased, thus suggesting a progressive uncoupling between QT duration and heart period that cannot be the result of influences unrelated to heart period changes

Open loop linear parametric modelling of the QT variability / A. Porta, E. Tobaldini, V. Magagnin, T. Bassani, T. Gnecchi-Ruscone, N. Montano - In: Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE[s.l] : IEEE Service Center, 2009. - ISBN 978-1-4244-3296-7. - pp. 6453-6456 (( Intervento presentato al 31. convegno Annual International Conference of the IEEE EMBS tenutosi a Minneapolis nel 2009 [10.1109/IEMBS.2009.5333541].

Open loop linear parametric modelling of the QT variability

A. Porta
Primo
;
E. Tobaldini
Secondo
;
N. Montano
Ultimo
2009

Abstract

Open loop linear parametric modeling approach was applied to describe the variability of the ventricular depolarization and repolarization duration (i.e. the QT interval from the ECG). Several model structures were compared. The model maximizing the goodness of fit describes the QT interval as a linear combination of its own past values plus two exogenous influences (i.e. heart period interval and respiration) and a colored noise. When this model was applied to a protocol imposing a progressive increase of the sympathetic activity and modulation (i.e. the graded head-up tilt), the goodness of fit gradually decreased, thus suggesting a progressive uncoupling between QT duration and heart period that cannot be the result of influences unrelated to heart period changes
Settore MED/09 - Medicina Interna
Settore ING-INF/06 - Bioingegneria Elettronica e Informatica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/217477
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