Acute otitis media (AOM) is a leading cause of visits to physicians and of antibiotic prescriptions for young children. We systematically reviewed studies on all-cause AOM episodes and physician visits in which impact was attributed to pneumococcal conjugate vaccines, either as efficacy or effectiveness. Of 18 relevant publications found, most used the 7-valent pneumococcal conjugate vaccine (7vCRM). The efficacy of 7vCRM against all-cause AOM episodes or visits was 0-9 in randomized trials and 17-23 in nonrandomized trials. In observational database studies, physician visits for AOM were already declining in the 3-5 years before 7vCRM introduction (mean change,-15; range, +14 to-24) and continued to decline afterward (mean,-19; range, +7 to-48). This vaccine provides some protection against OM, but other factors have also contributed to the recent decline in OM incidence. Future effectiveness studies should thus use better-controlled methods to estimate the true impact of vaccination on AOM.
|Titolo:||Impact of pneumococcal conjugate vaccination on otitis media: a systematic review|
|Autori interni:||MARCHISIO, PAOLA GIOVANNA (Corresponding)|
|Parole Chiave:||respiratory-tract infections; nontypable haemophilus-influenzae; United-States; controlled-trial; native children; tube placement; young-children; protein-D; efficacy; infants|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||giu-2012|
|Digital Object Identifier (DOI):||10.1093/cid/cis292|
|Appare nelle tipologie:||01 - Articolo su periodico|