Background: Alcohol is capable of traversing the blood-brain barrier and is thus a possible risk factor for brain cancer. Several epidemiological studies have been published on the issue, a number of those during recent years, with inconsistent findings. Materials and methods: We performed a systematic literature search in the Medline and EMBASE databases. We found a total of 19 studies providing risk estimates for total alcohol or specific alcoholic beverages. Pooled estimates of the relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models. Results: The pooled RR of brain cancer for alcohol drinkers versus non-drinkers was 0.97 (95% CI 0.82-1.15; based on 12 studies). Moderate (<2 drinks/day) and heavy alcohol drinkers had RRs of 1.01 (95% CI 0.81-1.25) and 1.35 (95% CI 0.85-2.15), respectively. With reference to specific alcoholic beverages, the RRs were 1.01 (95% CI 0.70-1.48) for wine, 0.96 (95% CI 0.82-1.12) for beer, and 1.20 (95% CI 1.01-1.42) for spirit consumption. The RRs for drinkers versus non-drinkers were 0.93 (95% CI 0.81-1.07) for glioma and 0.71 (95% CI 0.45-1.12) for meningioma. Conclusions: Alcohol drinking does not appear to be associated with adult brain cancer, though a potential effect of high doses deserves further study.
A meta-analysis of alcohol consumption and the risk of brain tumours / C. Galeone, S. Malerba, M. Rota, V. Bagnardi, E. Negri, L. Scotti, R. Bellocco, G. Corrao, P. Boffetta, C. La Vecchia, C. Pelucchi. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 24:2(2013 Feb), pp. mds432.514-mds432.523.
|Titolo:||A meta-analysis of alcohol consumption and the risk of brain tumours|
GALEONE, CARLOTTA (Primo)
LA VECCHIA, CARLO VITANTONIO BATTISTA (Penultimo)
|Parole Chiave:||Alcohol drinking; Brain neoplasms; Glioma; Meningioma; Meta-analysis; Risk factor|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||feb-2013|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/annonc/mds432|
|Appare nelle tipologie:||01 - Articolo su periodico|