The accurate detn. of radionuclidic purity and half-life of the beta emitter 177gLu used for metabolic radioimmunotherapy is presented. High-resoln. gamma spectrometry, as well as deconvolution of beta decay curve measured by spectrometry with liq. scintillation counting, have been adopted for quality control of different samples available on the market. A simple method was developed to distinguish between the different methods available for prodn. of 177gLu: i.e., either direct (n,γ) reactions of enriched 176Lu or indirect (n,γ) activation of enriched 176Yb followed by β- decay. In the first case, the long-lived metastable level 177mLu is present in the radioactive prepn. and a low specific activity radionuclide is obtained, in the latter a very high purity and high specific activity 177gLu is produced
Accurate determination of radionuclidic purity and half-life of reactor produced Lu-177G for metabolic radioimmunotherapy / F. Groppi, L. Canella, M.L. Bonardi, C. Zona, S. Morzenti, E. Menapace, Z.B. Alfassi, M. Chinol, S. Papi, G. Tosi - In: Astroparticle, particle and space physics, detectors and medical physics applications : proceedings of the 9th conference, Villa Olmo, Como, Italy, 17-21 October 2005 / [a cura di] M. Barone. - Singapore : World Scientific, 2006. - ISBN 9812567984. - pp. 710-714 (( Intervento presentato al 9. convegno Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications tenutosi a Como nel 2005 [10.1142/9789812773678_0112].
Accurate determination of radionuclidic purity and half-life of reactor produced Lu-177G for metabolic radioimmunotherapy
F. GroppiPrimo
;M.L. Bonardi;C. Zona;S. Morzenti;
2006
Abstract
The accurate detn. of radionuclidic purity and half-life of the beta emitter 177gLu used for metabolic radioimmunotherapy is presented. High-resoln. gamma spectrometry, as well as deconvolution of beta decay curve measured by spectrometry with liq. scintillation counting, have been adopted for quality control of different samples available on the market. A simple method was developed to distinguish between the different methods available for prodn. of 177gLu: i.e., either direct (n,γ) reactions of enriched 176Lu or indirect (n,γ) activation of enriched 176Yb followed by β- decay. In the first case, the long-lived metastable level 177mLu is present in the radioactive prepn. and a low specific activity radionuclide is obtained, in the latter a very high purity and high specific activity 177gLu is produced
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