Background. Organized cervical screening programs (CSPs) have been widely introduced in Italy. We aimed at retrieving screening history within CSPs of women with invasive cervical cancer (ICC) in areas covered by Cancer Registries. Methods. Screen-Detected (SD) women were those with a positive Pap-smear within a CSP, otherwise they were considered Non-Screen-Detected (NSD). Odds ratios (ORs) were calculated by logistic regression model adjusted for age. Results. Among 3473 women, aged 25-74 years and belonging to CSPs target in the period 1995-2008, 32.3% were SD and 67.7% were NSD. Among 2350 NSD women, 27.7% were never invited by CSP, 55.2% were never compliant to CSP, and 17.1% had a last negative Pap-smear within a CSP (53.5% of them <3.5 years before diagnosis). Compared to SD, NSD women were more frequently resident in the Center or South/Islands (ORs 1.4 and 7.8 vs. North, respectively) and born abroad (OR=1.6 vs. Italy); NSD had also more frequently non-squamous cells ICC histology (OR=1.5 vs. squamous) and higher ICC stages (OR=8.7 for FIGO III-IV vs. IA-IA1). Conclusion. In Italy, 68% of women with ICC were diagnosed outside CPSs, mainly because non compliance to CSP invitation. These women had more advanced tumor stages, with negative prognostic effects.

Screening history of women with cervical cancer in Italy / A. Zucchetto, G. Ronco, P. Giorgi Rossi, M. Zappa, A. Franzo, S. Ferretti, D. Serraino, I. CERVICE Working Group. ((Intervento presentato al 34. convegno International Association of Cancer Registries Conference tenutosi a Cork nel 2012.

Screening history of women with cervical cancer in Italy

A. Zucchetto
Primo
;
2012

Abstract

Background. Organized cervical screening programs (CSPs) have been widely introduced in Italy. We aimed at retrieving screening history within CSPs of women with invasive cervical cancer (ICC) in areas covered by Cancer Registries. Methods. Screen-Detected (SD) women were those with a positive Pap-smear within a CSP, otherwise they were considered Non-Screen-Detected (NSD). Odds ratios (ORs) were calculated by logistic regression model adjusted for age. Results. Among 3473 women, aged 25-74 years and belonging to CSPs target in the period 1995-2008, 32.3% were SD and 67.7% were NSD. Among 2350 NSD women, 27.7% were never invited by CSP, 55.2% were never compliant to CSP, and 17.1% had a last negative Pap-smear within a CSP (53.5% of them <3.5 years before diagnosis). Compared to SD, NSD women were more frequently resident in the Center or South/Islands (ORs 1.4 and 7.8 vs. North, respectively) and born abroad (OR=1.6 vs. Italy); NSD had also more frequently non-squamous cells ICC histology (OR=1.5 vs. squamous) and higher ICC stages (OR=8.7 for FIGO III-IV vs. IA-IA1). Conclusion. In Italy, 68% of women with ICC were diagnosed outside CPSs, mainly because non compliance to CSP invitation. These women had more advanced tumor stages, with negative prognostic effects.
18-set-2012
cervical cancer ; screening
Settore MED/01 - Statistica Medica
International Association of Cancer Registries (IACR)
http://www.iacr.com.fr/
Screening history of women with cervical cancer in Italy / A. Zucchetto, G. Ronco, P. Giorgi Rossi, M. Zappa, A. Franzo, S. Ferretti, D. Serraino, I. CERVICE Working Group. ((Intervento presentato al 34. convegno International Association of Cancer Registries Conference tenutosi a Cork nel 2012.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/213845
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