The straightforward immobilization of some derivatives of Cinchona alkaloids on modified poly(ethylene glycol)s is reported. The compounds, obtained by simple reactions exploiting different sites for the attachment of the alkaloids to the polymer, were tested as catalysts in the enantioselective benzylation of the benzophenone imine of glycine t-butyl ester (ee up to 64%) and in the conjugate addition of thiophenol to cyclohexenone (ee 22%). The observed stereoselectivities were compared to those obtained either with the unsupported catalysts or with the catalysts immobilized on different polymeric matrixes. The influence of the poly(ethylene glycol) moieties on the catalytic activity is discussed.
|Titolo:||Immobilization of catalysts derived from Cinchona alkaloids on modified poly(ethylene glycol)|
ANNUNZIATA, RITA MARIA (Secondo)
COZZI, FRANCO (Penultimo)
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||2003|
|Digital Object Identifier (DOI):||10.1016/S0957-4166(02)00830-3|
|Appare nelle tipologie:||01 - Articolo su periodico|