Pulmonary inflammation often results in expression of the class II major histocompatibility complex (MHCII) by both professional antigen-presenting cells (APCs; histiocytes and lymphocytes) and non-professional APCs (respiratory epithelium and endothelium). In this study lesions from 17 cases of bovine chronic pneumonia, associated with Mycoplasma bovis infection, were examined immunohistochemically for M. bovis antigen and MHCII expression. Ten cases of chronic necrosuppurative bronchopneumonia (NBP) were shown to be characterized by abundant perinecrotic M. bovis antigen associated with scant MHCII expression by degenerate leucocytes. Seven cases of chronic catarrhal bronchointerstitial pneumonia (CBP) showed prominent MHCII expression by both professional APCs and respiratory epithelium, in the absence of intralesional M. bovis immunolabelling. The results suggest that prominent MHCII expression by both professional and non-professional APCs plays a role in the pathogenesis of M. bovis-induced CBP. Conversely, the role of MHCII expression in necrosuppurative foci typical of M. bovis-associated NBP can be considered negligible.
Expression of class II major histocompatibility complex molecules in chronic pulmonary Mycoplasma bovis infection in cattle / E. Radaelli, M. Luini, C. Domeneghini, G. R. Loria, C. Recordati, P. Radaelli, E. Scanziani. - In: JOURNAL OF COMPARATIVE PATHOLOGY. - ISSN 0021-9975. - 140:2-3(2009), pp. 198-202.
|Titolo:||Expression of class II major histocompatibility complex molecules in chronic pulmonary Mycoplasma bovis infection in cattle|
RADAELLI, ENRICO (Primo)
SCANZIANI, EUGENIO (Ultimo)
|Parole Chiave:||bacterial infection; cattle; MHCII; Mycoplasma bovis; pneumonia|
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jcpa.2008.10.008|
|Appare nelle tipologie:||01 - Articolo su periodico|