Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
Epithelial-mesenchymal transition in mouse mammary tumorigenesis / E. Radaelli, P. Damonte, R. D. Cardiff. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 5:8(2009 Oct), pp. 1113-27-1127.
Epithelial-mesenchymal transition in mouse mammary tumorigenesis
E. RadaelliPrimo
;
2009
Abstract
Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
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