Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.

Epithelial-mesenchymal transition in mouse mammary tumorigenesis / E. Radaelli, P. Damonte, R. D. Cardiff. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 5:8(2009 Oct), pp. 1113-27-1127.

Epithelial-mesenchymal transition in mouse mammary tumorigenesis

E. Radaelli
Primo
;
2009

Abstract

Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
E-cadherin; Epithelial-mesenchymal transition; Genetically engineered mice; Heterogeneity; Invasion; Metastasis; Mouse mammary tumors; Pathology; Snail; Spindle cell phenotype
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
ott-2009
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/212376
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