Five heterozygous familial hypercholesterolemia patients have been treated with LDL-apheresis for a period of three months. The apheretic procedure was repeated four times at both biweekly and weekly intervals. A dextran-sulfate cellulose regenerating unit was used, processing one plasma volume at each time. The efficiency of the apheretic procedure was similar at both weekly and biweekly intervals, removing 60–70% of total cholesterol (TC), LDL cholesterol (LDL-C) and apo B. Weekly treatment was however more effective in lowering plasma lipid-lipoprotein levels: pre-apheresis TC, LDL-C and apo B levels were, in fact, 23–25% higher during the biweekly treatment.
Efficiency and efficacy of LDL-apheresis performed at different intervals / G. Franceschini, L. Calabresi, G. Chiesa, G. Busnach. - (1990), pp. 487-491. (Intervento presentato al 7. convegno Meeting on atherosclerosis and cardiovascular disease tenutosi a Bologna nel 1989) [10.1007/978-94-009-0731-7_62].
Efficiency and efficacy of LDL-apheresis performed at different intervals
G. FranceschiniPrimo
;L. CalabresiSecondo
;G. ChiesaPenultimo
;
1990
Abstract
Five heterozygous familial hypercholesterolemia patients have been treated with LDL-apheresis for a period of three months. The apheretic procedure was repeated four times at both biweekly and weekly intervals. A dextran-sulfate cellulose regenerating unit was used, processing one plasma volume at each time. The efficiency of the apheretic procedure was similar at both weekly and biweekly intervals, removing 60–70% of total cholesterol (TC), LDL cholesterol (LDL-C) and apo B. Weekly treatment was however more effective in lowering plasma lipid-lipoprotein levels: pre-apheresis TC, LDL-C and apo B levels were, in fact, 23–25% higher during the biweekly treatment.
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