The aim of this work is to evaluate the development of X.l. in modified gravity conditions. The simulation of hyper and microgravity was performed utilizing: an hyperfuge, a Clinostat and later on a Random Positioning Machine (RPM, 3d Clinostat). The effect of hypergravity on embryos is significantly higher than that of microgravity; the exposure of embryos to 3xg for 3 days before and after hatch causes an activation of HSP-60 and HSP-70. Embryos exposed to 3xg during the first 3 days of development are very sensitive and show a retard of development, with a lower content of DNA, neutral glycolipids and gangliosides compared to controls.
Effects of microgravity and hypergravity on early developmental stages of Xenopus laevis / A. Rizzo, F. Rossi, A. Guerra, P. Pippia, M. Meloni, B. Berra - In: Proceedings of Life in space for life on earth / [a cura di] B. Warmbein. - Noordwijk : ESA, 2002. - ISBN 9290928115. - pp. 315-316 (( Intervento presentato al 8. convegno European Symposium on Life Science Research in Space ; 23rd Annual International Gravitational Physiology Meeting tenutosi a Stockholm nel 2002.
Effects of microgravity and hypergravity on early developmental stages of Xenopus laevis
A. Rizzo
;
2002
Abstract
The aim of this work is to evaluate the development of X.l. in modified gravity conditions. The simulation of hyper and microgravity was performed utilizing: an hyperfuge, a Clinostat and later on a Random Positioning Machine (RPM, 3d Clinostat). The effect of hypergravity on embryos is significantly higher than that of microgravity; the exposure of embryos to 3xg for 3 days before and after hatch causes an activation of HSP-60 and HSP-70. Embryos exposed to 3xg during the first 3 days of development are very sensitive and show a retard of development, with a lower content of DNA, neutral glycolipids and gangliosides compared to controls.
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