As opposed to a number of other pharmacological agents, ivabradine expresses high selectivity and specificity for its target. Ivabradine exerts a unique action on cardiac pacemaker activity, based on its block of the hyperpolarization-activated, cyclic nucleotide-gated channels that pass the pacemaker current, If. In doing so, it suppresses but does not stop the sinoatrial pacemaker's rate of firing. In the following pages, we will review the mechanisms of normal pacemaker activity in the heart, discuss ivabradine's mechanism of action, and then review the advantages of heart rate reduction in clinical settings as well as other potential applications of the drug.
|Titolo:||I-f modulation: perspectives in clinical medicine|
BUCCHI, ANNALISA (Secondo)
|Parole Chiave:||Angina pectoris; Heart rate; Ivabradine; Pacemaker current|
|Settore Scientifico Disciplinare:||Settore BIO/09 - Fisiologia|
|Data di pubblicazione:||2006|
|Digital Object Identifier (DOI):||10.1093/eurheartj/sul018|
|Appare nelle tipologie:||01 - Articolo su periodico|