Interaction between glial and neuronal cells seems to be necessary for the correct neuronal function and modifications of neuro-glial network strongly contribute to several neurodegenerative processes. Based on NGF activity on DRG and sensory neurons in the spinal cord, we have used the Spared Nerve Injury (SNI) rat model to investigate the role of endogenous NGF in maintaining homeostatic synaptic conditions. We found that restoring the balance of NGF maturation and degradation reduces neuropathic behaviour by reverting the alterations of neuronal and glial components. In addiction, by using neuronally differentiated PC12 cell, we identify a novel mechanism of neuroprotection by NGF that involves modulation of mitochondrial function and autophagy.

Role of Endogenous NGF in Modulation of Neuro-glial Network in the Spinal Cord of a Rat Model of Neuropathic Pain / M.R. Bianco, A.M. Colangelo, G. Cirillo, S. Viggiani, M. Fragni, D. Chianese, F. Amara, V. Galimberti, L. Alberghina, M. Papa. ((Intervento presentato al convegno Sysbiohealth Symposium 2009 tenutosi a Milano nel 2009.

Role of Endogenous NGF in Modulation of Neuro-glial Network in the Spinal Cord of a Rat Model of Neuropathic Pain

A.M. Colangelo
Secondo
;
M. Fragni;F. Amara;
2009

Abstract

Interaction between glial and neuronal cells seems to be necessary for the correct neuronal function and modifications of neuro-glial network strongly contribute to several neurodegenerative processes. Based on NGF activity on DRG and sensory neurons in the spinal cord, we have used the Spared Nerve Injury (SNI) rat model to investigate the role of endogenous NGF in maintaining homeostatic synaptic conditions. We found that restoring the balance of NGF maturation and degradation reduces neuropathic behaviour by reverting the alterations of neuronal and glial components. In addiction, by using neuronally differentiated PC12 cell, we identify a novel mechanism of neuroprotection by NGF that involves modulation of mitochondrial function and autophagy.
Neuro-glial network, NGF, neuronal apoptosis, mitochondria, reactive gliosis, glutamate transporters
Settore BIO/10 - Biochimica
Settore BIO/11 - Biologia Molecolare
Centro di Eccellenza per le Biotecnologie Industriali - CEBIB
Role of Endogenous NGF in Modulation of Neuro-glial Network in the Spinal Cord of a Rat Model of Neuropathic Pain / M.R. Bianco, A.M. Colangelo, G. Cirillo, S. Viggiani, M. Fragni, D. Chianese, F. Amara, V. Galimberti, L. Alberghina, M. Papa. ((Intervento presentato al convegno Sysbiohealth Symposium 2009 tenutosi a Milano nel 2009.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/211566
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