Morphine, intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) administered to rats, inhibited intestinal propulsion as tested by a charcoal meal. Such an inhibition was shown to be linearly related to the log of administered doses for both routes of administration and the two linear regressions are parallel, so that morphine was calculated to be 206 times more potent when administered i.c.v. than i.p. A dose of morphine fully active by the i.c.v. route was completely inactive when injected by the i.v., i.p., i.m. and s.c. routes. Naloxone, administered i.c.v., blocked the antipropulsive effect of morphine i.c.v. or i.p. The pA2 of naloxone versus morphine, both administered i.c.v. was determined and calculated to be 7.14 (6.76-7.62).
Effect of intracerebroventricular administration of morphine upon intestinal motility in rat and its antagonism with naloxone. / D. Parolaro, M. Sala, E. Gori. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 46:4(1977 Dec 15), pp. 329-338.
|Titolo:||Effect of intracerebroventricular administration of morphine upon intestinal motility in rat and its antagonism with naloxone.|
SALA, MARIAELVINA (Secondo)
|Parole Chiave:||Intestinal motility; Morphine; Naloxone; pA2 morphine/naloxone|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||15-dic-1977|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0014-2999(77)90227-8|
|Appare nelle tipologie:||01 - Articolo su periodico|