BACKGROUND: This study analyzed the incidence and the predictive factors of postoperative acute kidney injury (AKI) after thoracic endovascular aortic repair (TEVAR) and evaluated the effect of AKI on postoperative survival. METHODS: Between November 2000 and April 2011, all consecutive patients undergoing TEVAR of the descending thoracic or thoracoabdominal aorta were enrolled at four teaching hospitals. Estimated glomerular filtration rate (eGFR) was evaluated during the entire hospitalization. AKI was defined by the RIFLE (Risk, Injury, Failure, Loss of function, End-stage renal disease) consensus criteria. RESULTS: The study included 171 patients (80% men) who were a mean age of 69 ± 14 years (range, 18-87 years). AKI occurred in 24 patients (14%). Independent predictors of postoperative AKI were preoperative depressed eGFR, thoracoabdominal extent, and postoperative transfusion. Patients with AKI experienced major postoperative complications (P = .001), longer hospitalization (P = .008), and higher hospital mortality (29% vs 4%; P < .001). Kaplan-Meier analysis showed a survival of 82%, 51%, and 51% at 1, 3, and 5 years, for patients who developed AKI, which was significantly worse than the 99%, 89%, and 80% for patients who did not experience AKI (P = .001). CONCLUSIONS: Preoperative poor renal function, blood transfusions, and the thoracoabdominal extent of the aortic disease were the most important predictors for AKI.
Predictors and outcomes of acute kidney injury after thoracic aortic endograft repair / G. Piffaretti, G. Mariscalco, S. Bonardelli, A. Sarcina, G. Gelpi, R. Bellosta, M. De Lucia, F. Nodari, E. Cervi, G. Carrafiello, C. Antona, P. Castelli. - In: JOURNAL OF VASCULAR SURGERY. - ISSN 0741-5214. - 56:6(2012 Oct 08), pp. 1527-1534.
|Titolo:||Predictors and outcomes of acute kidney injury after thoracic aortic endograft repair|
ANTONA, CARLO (Penultimo)
|Parole Chiave:||aortic endovascular repair ; aortic aneurism ; thoraco abdominal aneurism ; aortic endograft|
|Settore Scientifico Disciplinare:||Settore MED/23 - Chirurgia Cardiaca|
|Data di pubblicazione:||8-ott-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jvs.2012.05.106|
|Appare nelle tipologie:||01 - Articolo su periodico|
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