We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.
IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai / M. Biasin, A. Boasso, L. Piacentini, D. Trabattoni, G. Magri, R. Deshmuks, A. Deshpande, M. Clerici. - In: AIDS. - ISSN 0269-9370. - 17:10(2003), pp. 1563-1566.
Titolo: | IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai |
Autori: | BIASIN, MARA (Primo) BOASSO, ADRIANO (Secondo) CLERICI, MARIO SALVATORE (Ultimo) |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
Data di pubblicazione: | 2003 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/00002030-200307040-00019 |
Appare nelle tipologie: | 01 - Articolo su periodico |