We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.
IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai / M. Biasin, A. Boasso, L. Piacentini, D. Trabattoni, G. Magri, R. Deshmuks, A. Deshpande, M. Clerici. - In: AIDS. - ISSN 0269-9370. - 17:10(2003), pp. 1563-1566.
|Titolo:||IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai|
BIASIN, MARA (Primo)
BOASSO, ADRIANO (Secondo)
CLERICI, MARIO SALVATORE (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2003|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/00002030-200307040-00019|
|Appare nelle tipologie:||01 - Articolo su periodico|