A method for the determination of benzene, toluene, ethylbenzene and xylenes (BTEX) in urine of people exposed to these airborne pollutants present in the living environment, has been described. Solid-phase microextraction has been used for sampling BTEX from the headspace of urine and gas chromatography-mass spectrometry has been applied for the selective analysis of chemicals. The method has the following features: small volume of urine (2 ml) needed, linearity in the range of interest (from the limit of detection up to 5000 ng/l) with coefficient of correlation > or =0.998, limit of detection in the range 12-34 ng/l, good repeatability (coefficient of variation 2-7%), high specificity. The stability of the urine sample during storage (-20 degrees C) was evaluated: BTEX remained stable for up to 2 months. The assay has been successfully applied to the biological monitoring of two subjects environmentally exposed to airborne BTEX in an urban area.
Headspace solid-phase microextraction for the determination of benzene, toluene, ethylbenzene and xylenes in urine / S. Fustinoni, R.E.P. Giampiccolo, S.M.A. Pulvirenti, M. Buratti, A.L.P. Colombi. - In: JOURNAL OF CHROMATOGRAPHY B. BIOMEDICAL SCIENCES AND APPLICATIONS. - ISSN 1387-2273. - 723:1-2(1999 Feb 19), pp. 105-115.
|Titolo:||Headspace solid-phase microextraction for the determination of benzene, toluene, ethylbenzene and xylenes in urine|
FUSTINONI, SILVIA (Corresponding)
GIAMPICCOLO, ROSARIO EMANUELE PAOLO (Secondo)
COLOMBI, ANTONIO LUCIANO PAOLO (Ultimo)
|Parole Chiave:||benzene; toluene; ethylbenzene; xylene|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Data di pubblicazione:||19-feb-1999|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0378-4347(98)00515-5|
|Appare nelle tipologie:||01 - Articolo su periodico|