The nervous system, like the classical peripheral endocrine glands, e.g. gonads, placenta and adrenal glands, is now considered a steroidogenic organ. Hence, the name “neurosteroids” was coined to indicate properly steroids synthesized in the nervous system. Successively, it was introduced also the term “neuroactive steroids” which includes both the neurosteroids and the classical peripheral hormonal steroids that are metabolized to neuroactive compounds in the nervous system. The neuroactive steroids, via the interactions with the classic and non-classic steroid hormone receptors, exert several effects at the level of the neuronal and non-neuronal cellular compartments. Among these, glial cells, not only represent an important target for the action of neuroactive steroids but are also deputed to synthesize neurosteroids. In this chapter we will summarize the neusteroidogenesis pathways and describe the main functions exerted by neuroactive steroids on these cells.

Role of neuroactive steroids in glial cells of the central and peripheral nervous system / V. Magnaghi, R.C. Melcangi - In: Recent research developments in neuroscience / [a cura di] S.G. Pandalai. - Trivandrum : Research Signpost, 2004. - ISBN 81-7736-207-0. - pp. 81-102

Role of neuroactive steroids in glial cells of the central and peripheral nervous system

V. Magnaghi
Primo
;
R.C. Melcangi
Ultimo
2004

Abstract

The nervous system, like the classical peripheral endocrine glands, e.g. gonads, placenta and adrenal glands, is now considered a steroidogenic organ. Hence, the name “neurosteroids” was coined to indicate properly steroids synthesized in the nervous system. Successively, it was introduced also the term “neuroactive steroids” which includes both the neurosteroids and the classical peripheral hormonal steroids that are metabolized to neuroactive compounds in the nervous system. The neuroactive steroids, via the interactions with the classic and non-classic steroid hormone receptors, exert several effects at the level of the neuronal and non-neuronal cellular compartments. Among these, glial cells, not only represent an important target for the action of neuroactive steroids but are also deputed to synthesize neurosteroids. In this chapter we will summarize the neusteroidogenesis pathways and describe the main functions exerted by neuroactive steroids on these cells.
Settore MED/13 - Endocrinologia
Settore BIO/09 - Fisiologia
2004
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/210454
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