Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovative IGF-I Kinase Receptor Activation (KIRA) Assay, total IGF-I, IGFBP-3, total IGF-II, insulin, glucose, HOMA2-B% and HOMA2-S% in 192 centenarians' offspring and 80 offspring-controls of which both parents died relatively young. Both groups were well-matched for age, gender and BMI with the centenarians' offspring. IGF-I bioactivity (p〈0.01), total IGF-I (p〈0.01) and the IGF-I/IGFBP-3 molar ratio (p〈0.001) were significantly lower in centenarians' offspring compared to offspring matched-controls. Serum insulin, glucose, HOMA2-B% and HOMA2-S% values were similar between both groups. In centenarians' offspring IGF-I bioactivity was inversely associated to insulin sensitivity. In conclusion: 1) centenarians' offspring had relatively lower circulating IGF-I bioactivity compared to offspring matched-controls; 2) IGF-I bioactivity in centenarians' offspring was inversely related to insulin sensitivity. These data support a role of the IGF-I/insulin system in the modulation of human aging process.
Low circulating IGF-I bioactivity is associated with human longevity : findings in centenarians' offspring / G. Vitale, M.P. Brugts, G. Ogliari, D. Castaldi, L.M. Fatti, A.J. Varewijck, S.W. Lamberts, D. Monti, L. Bucci, E. Cevenini, F. Cavagnini, C. Franceschi, L.J. Hofland, D. Mari, J. Janssen. - In: AGING. - ISSN 1945-4589. - 4:9(2012 Sep), pp. 580-589.
|Titolo:||Low circulating IGF-I bioactivity is associated with human longevity : findings in centenarians' offspring|
VITALE, GIOVANNI (Primo)
MARI, DANIELA (Penultimo)
|Parole Chiave:||centenarians; centenarians' offspring; IGF-I bioactivity; IGF-I receptors; insulin receptors; longevity|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
Settore MED/09 - Medicina Interna
|Data di pubblicazione:||set-2012|
|Appare nelle tipologie:||01 - Articolo su periodico|