Hair follicle (HF) regression is characterized by the activation of apoptosis in HF cells. Dermal papilla cells play a leading role in the regulation of HF development and cycling. Human follicular dermal papilla cells (HFDPC) were used to investigate the protective activities of rutin, sperimidine and zeaxanthine. HFDP cell incubation with staurosporine caused apoptosis, which was completely inhibited by exposure to rutin (2.2 mu m), spermidine (1 mu m) and zeaxanthin (80 mu m). These agents were much less effective when applied as single compounds. Moreover, treatment preserved the expression of anti-apoptotic molecules such as Bcl-2, MAP-kinases and their phosphorylated forms. In conclusion, the investigated agents may represent an effective treatment for the prevention of apoptosis, one of the leading events involved in hair bulb regression.

A specific combination of zeaxanthin, spermidine and rutin prevents apoptosis in human dermal papilla cells / S. Carelli, D. Hebda, M.V. Traversa, F. Messaggio, G. Giuliani, B. Marzani, A. Benedusi, A.M. Di Giulio, A. Gorio. - In: EXPERIMENTAL DERMATOLOGY. - ISSN 0906-6705. - 21:12(2012 Dec), pp. 953-955. [10.1111/exd.12029]

A specific combination of zeaxanthin, spermidine and rutin prevents apoptosis in human dermal papilla cells

S. Carelli;D. Hebda;M.V. Traversa;F. Messaggio;A.M. Di Giulio;A. Gorio
2012-12

Abstract

Hair follicle (HF) regression is characterized by the activation of apoptosis in HF cells. Dermal papilla cells play a leading role in the regulation of HF development and cycling. Human follicular dermal papilla cells (HFDPC) were used to investigate the protective activities of rutin, sperimidine and zeaxanthine. HFDP cell incubation with staurosporine caused apoptosis, which was completely inhibited by exposure to rutin (2.2 mu m), spermidine (1 mu m) and zeaxanthin (80 mu m). These agents were much less effective when applied as single compounds. Moreover, treatment preserved the expression of anti-apoptotic molecules such as Bcl-2, MAP-kinases and their phosphorylated forms. In conclusion, the investigated agents may represent an effective treatment for the prevention of apoptosis, one of the leading events involved in hair bulb regression.
dermal papilla cells; hair follicle; rutin; spermidine; zeaxanthin
Settore BIO/14 - Farmacologia
EXPERIMENTAL DERMATOLOGY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/210017
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