Apolipoprotein (apo) A-I, because of its anti-atherogenic properties, represents a powerful approach to the management of vascular diseases. Infusion of apoA-I-containing synthetic high-density lipoprotein (HDL) inhibits atherosclerosis progression or prevents restenosis in experimental animals, and apoA-I liposomes are capable of stimulating reverse cholesterol transport in humans. Moreover, many experimental studies have been conducted with a molecular variant of apoA-I, apoA-I(Milano), characterized by a prolonged residence time in plasma and improved function, which may offer an even better approach to the therapeutic handling of arterial disease.

Use of recombinant apolipoproteins in vascular diseases: the case of apoA-I / G. Chiesa, C.R. Sirtori. - In: CURRENT OPINION IN INVESTIGATIONAL DRUGS. - ISSN 1472-4472. - 3:3(2002 Mar), pp. 420-426.

Use of recombinant apolipoproteins in vascular diseases: the case of apoA-I

G. Chiesa
Primo
;
C.R. Sirtori
Ultimo
2002

Abstract

Apolipoprotein (apo) A-I, because of its anti-atherogenic properties, represents a powerful approach to the management of vascular diseases. Infusion of apoA-I-containing synthetic high-density lipoprotein (HDL) inhibits atherosclerosis progression or prevents restenosis in experimental animals, and apoA-I liposomes are capable of stimulating reverse cholesterol transport in humans. Moreover, many experimental studies have been conducted with a molecular variant of apoA-I, apoA-I(Milano), characterized by a prolonged residence time in plasma and improved function, which may offer an even better approach to the therapeutic handling of arterial disease.
Apolipoprotein; Atherosclerosis; Cholesterol; High-density lipoprotein
Settore BIO/14 - Farmacologia
mar-2002
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/209795
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