Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as preliminary. Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.

Beware of surrogate outcome measures / P.C. Gøtzsche, A. Liberati, V. Torri, L. Rossetti. - In: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. - ISSN 0266-4623. - 12:2(1996), pp. 238-246.

Beware of surrogate outcome measures

L. Rossetti
Ultimo
1996

Abstract

Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as preliminary. Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.
controlled trial ; clinical-trials ; glaucoma
Settore MED/30 - Malattie Apparato Visivo
1996
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/209524
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