Current approved medical therapies for endometriosis rely on drugs that suppress ovarian steroids and induce a hypoestrogenic state, which determines the atrophy of the ectopic endometrium. Gonadotropin-releasing hormone analogs such as danazol, progestogens and estrogen-progestin combinations have all proven effective in relieving pain and reducing the extent of endometriotic implants. However, symptoms often recur after discontinuation of therapy and hypoestrogenism-related side effects limit the long-term use of most medications. Recently, knowledge of the pathogenesis of endometriosis, particularly at the molecular level, has grown substantially, providing a rational basis for the development of new drugs with precise targets that may be safely administered over the long term.

Medical management of endometriosis / L. Fedele, S. Bianchi, E. Fontana, N. Berlanda, G. Frontino, A. Bulfoni. - In: WOMEN'S HEALTH. - ISSN 1745-5057. - 2:2(2006 Mar), pp. 297-308.

Medical management of endometriosis

L. Fedele;S. Bianchi;FONTANA, ELEONORA;N. Berlanda;G. Frontino;
2006-03

Abstract

Current approved medical therapies for endometriosis rely on drugs that suppress ovarian steroids and induce a hypoestrogenic state, which determines the atrophy of the ectopic endometrium. Gonadotropin-releasing hormone analogs such as danazol, progestogens and estrogen-progestin combinations have all proven effective in relieving pain and reducing the extent of endometriotic implants. However, symptoms often recur after discontinuation of therapy and hypoestrogenism-related side effects limit the long-term use of most medications. Recently, knowledge of the pathogenesis of endometriosis, particularly at the molecular level, has grown substantially, providing a rational basis for the development of new drugs with precise targets that may be safely administered over the long term.
Amenorrhea; Dysmenorrhea; Dyspareunia; Endometriosis; Hormonal treatment; Medical treatment; Pelvic pain
Settore MED/40 - Ginecologia e Ostetricia
WOMEN'S HEALTH
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/209111
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