The mechanisms underlying secondary cell death after traumatic brain injury (TBI) are poorly understood. Animal models of TBI recapitulate many clinical and pathologic aspects of human head injury, and the development of genetically engineered animals has offered the opportunity to investigate the specific molecular and cellular mechanisms associated with cell dysfunction and death after TBI, allowing for the evaluation of specific cause-effect relations and mechanistic hypotheses. This article represents a compendium of the current literature using genetically engineered mice in studies designed to better understand the posttraumatic inflammatory response, the mechanisms underlying DNA damage, repair, and cell death, and the link between TBI and neurodegenerative diseases.

A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury / L. Longhi, K.E. Saatman, R. Raghupathi, H.L. Laurer, P.M. Lenzlinger, P. Riess, E. Neugebauer, J.Q. Trojanowski, V.M. Lee, M.S. Grady, D.I. Graham, T.K. McIntosh. - In: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. - ISSN 0271-678X. - 21:11(2001 Nov), pp. 1241-1258.

A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury

L. Longhi
Primo
;
2001-11

Abstract

The mechanisms underlying secondary cell death after traumatic brain injury (TBI) are poorly understood. Animal models of TBI recapitulate many clinical and pathologic aspects of human head injury, and the development of genetically engineered animals has offered the opportunity to investigate the specific molecular and cellular mechanisms associated with cell dysfunction and death after TBI, allowing for the evaluation of specific cause-effect relations and mechanistic hypotheses. This article represents a compendium of the current literature using genetically engineered mice in studies designed to better understand the posttraumatic inflammatory response, the mechanisms underlying DNA damage, repair, and cell death, and the link between TBI and neurodegenerative diseases.
cell death ; head injury ; inflammation ; neurodegeneration ; pathophysiology ; secondary brain damage ; transgenic mice
Settore MED/41 - Anestesiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/209060
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