Antigenic alterations of experimental lymphomas can be induced by a proper treatment with antineoplastic agents. While immunologic properties of drug-treated tumors have received some attention, surface characteristic of altered cells have found scant interest. Reduced susceptibility to Con A agglutination of L1210/DTIC cells and EL4/DTIC cells in respect to L1210 and EL4 parental cells has been obtained. Following adsorbing assays and agglutination inhibition assays by the sugar moiety αMM, similar amount of Con A has been bound by either original or by DTIC-treated cells. Con A binding sites on cell membranes of experimental lymphomas have not been modified by the DTIC treatment, however the mobility of surface molecules is likely to be altered.

Con A agglutination of DTIC-altered lymphoma cells / G. Nicolotti, P. Gelfi, O. Marelli, A. Nicolin. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 10:4(1978 Apr), pp. 313-324.

Con A agglutination of DTIC-altered lymphoma cells

O. Marelli
Penultimo
;
1978-04

Abstract

Antigenic alterations of experimental lymphomas can be induced by a proper treatment with antineoplastic agents. While immunologic properties of drug-treated tumors have received some attention, surface characteristic of altered cells have found scant interest. Reduced susceptibility to Con A agglutination of L1210/DTIC cells and EL4/DTIC cells in respect to L1210 and EL4 parental cells has been obtained. Following adsorbing assays and agglutination inhibition assays by the sugar moiety αMM, similar amount of Con A has been bound by either original or by DTIC-treated cells. Con A binding sites on cell membranes of experimental lymphomas have not been modified by the DTIC treatment, however the mobility of surface molecules is likely to be altered.
Animals ; Dacarbazine ; Mice ; Leukemia L1210 ; Mice, Inbred DBA ; Triazenes ; Agglutination ; Concanavalin A ; Cells, Cultured ; Adsorption ; Mice, Inbred C57BL ; Lymphoma ; Female ; Male
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/209054
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