Antigenic alterations of experimental lymphomas can be induced by a proper treatment with antineoplastic agents. While immunologic properties of drug-treated tumors have received some attention, surface characteristic of altered cells have found scant interest. Reduced susceptibility to Con A agglutination of L1210/DTIC cells and EL4/DTIC cells in respect to L1210 and EL4 parental cells has been obtained. Following adsorbing assays and agglutination inhibition assays by the sugar moiety αMM, similar amount of Con A has been bound by either original or by DTIC-treated cells. Con A binding sites on cell membranes of experimental lymphomas have not been modified by the DTIC treatment, however the mobility of surface molecules is likely to be altered.
|Titolo:||Con A agglutination of DTIC-altered lymphoma cells|
MARELLI, ORNELLA (Penultimo)
|Parole Chiave:||Animals ; Dacarbazine ; Mice ; Leukemia L1210 ; Mice, Inbred DBA ; Triazenes ; Agglutination ; Concanavalin A ; Cells, Cultured ; Adsorption ; Mice, Inbred C57BL ; Lymphoma ; Female ; Male|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||apr-1978|
|Digital Object Identifier (DOI):||10.1016/S0031-6989(78)80026-5|
|Appare nelle tipologie:||01 - Articolo su periodico|