Clinics and pathology Disease Acute non lymphocytic leukaemia (ANLL) Epidemiology +4 as the sole anomaly is a rare chromosomal abnormality associated with a specific subtype of primary ANLL and secondary (treatment related) ANLL with myelomonocytic morphology; it has been found with the same frequence in the M1-M2 and M4 French-American-British (FAB) phenotypes. Association of +4 with double minute chromosomes has been described in ten cases; five with AML-M2, two with AML-M4, one with refractory anemia with excess of blasts in transformation (RAEB-T), one with chronic myelomonocytic leukemia (CMMoL) and one with unclassified preleukemia. The coincidence of +4 with t(8;21) or its variant t(6;21;8), observed in at least two cases of ANLL (M1 and M2), is therefore recurrent.
+4 or trisomy 4 / A. Beghini. - In: ATLAS OF GENETICS AND CYTOGENETICS IN ONCOLOGY AND HAEMATOLOGY. - ISSN 1768-3262. - 4:3(2000 Jul), pp. 129-130.
|Titolo:||+4 or trisomy 4|
BEGHINI, ALESSANDRO (Primo)
|Settore Scientifico Disciplinare:||Settore MED/03 - Genetica Medica|
|Data di pubblicazione:||lug-2000|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.4267/2042/37648|
|Appare nelle tipologie:||01 - Articolo su periodico|