Estrogens locally generated from androgen precursors due to the action of aromatase play a main role in epiphyseal cartilage fusion. Treatment with an aromatase inhibitor (anastrozole, 1 mg/day for 3 yr) in a boy previously operated on for a hamartoma causing precocious puberty and presenting with advanced bone maturation and nearly fused epiphyseal cartilages, slowed cartilage fusion consenting a higher final stature than expected (164.4 cm vs 158.4 cm). It is suggested that treatment with aromatase inhibitors, alone or in combination with rh-GH, may also be useful in children with constitutional short stature in order to delay epiphyseal closure and improve the final height.
|Titolo:||Delayed closure of epiphyseal cartilages induced by the aromatase inhibitor anastrozole : would it help short children grow up?|
AROSIO, MAURA (Secondo)
|Parole Chiave:||Anastrozole; Aromatase inhibitors; Epiphyseal closure; Growth; Precocious puberty; Short stature|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||dic-2000|
|Digital Object Identifier (DOI):||10.1007/BF03345059|
|Appare nelle tipologie:||01 - Articolo su periodico|