In the perspective of clinical translation of stem cell research, the possibility to detect donor cells after transplantation and to track their fate is fundamental for a better understanding of their role in the regeneration of damaged tissues. In this article we summarize the results of ex-vivo and in-vivo X-ray computed microtomography experiments for 3D visualization of stem cells labeled with iron oxide nanoparticles and transplanted via intra-arterial infusion. We show that X-ray computed microtomography offers the possibility to detect with high definition and resolution human cells after transplantation, and opens new possibilities for experimental stem cell research.
|Titolo:||Synchrotron radiation microtomography for the ex-vivo and in-vivo evaluation of nanoparticle-labeled stem cell homing in muscular tissue|
TORRENTE, YVAN (Ultimo)
|Parole Chiave:||Muscular dystrophy; Nanoparticle labeling; Stem cells; X-ray computed microtomography|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||2010|
|Appare nelle tipologie:||01 - Articolo su periodico|