Cytokines/chemokines are involved in the immune response of infections, including HIV-1. We defined the profile of 48 cytokines/chemokines in cerebrospinal fluid from 18 cART patients with chronic HIV-1 infection by Luminex technology. Nine patients were affected with leukoencephalopathies: five with John Cunningham virus (JCV) + progressive multifocal leukoencephalopathy (PML) and four with JCV-not determined leukoencephalopathy (NDLE). In addition, nine HIV-1-positive patients with no neurological signs (NND) and five HIV-1-negative patients affected with acute disseminated encephalomyelitis (ADEM) were enrolled. Ten cytokines (IL-15, IL-3, IL-16, IL-18, CTACK, GRO1, SCF, MCP-1, MIF, SDF) were highly expressed in HIV-1-positive patients while IL-1Ra and IL-17 were present at a lower level. In addition, the levels of IL-17, IL-9, FGF-basic, MIP-1β, and MCP-1 were significantly higher (p < 0.05) in patients with neurological diseases (PML, NDLE, ADEM) with respect to NND. Focusing the attention to the cytokine profile in JCV + PML patients with respect to JCV-NDLE patients, only TNF-β was significantly downregulated (p < 0.05) in JCV + PML patients. This pilot study emphasized the role of immunoregulation in HIV-1-related neurological disorders during cART treatment

Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders / V. ZANIN, S. DELBUE, A. MARCUZZI, E. TAVAZZI, R. DEL SAVIO, S. CROVELLA, E. MARCHIONI, P. FERRANTE, M. COMAR. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - 18:5(2012), pp. 412-422. [10.1007/s13365-012-0109-y]

Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders

S. Delbue
Secondo
;
P. Ferrante
Penultimo
;
2012

Abstract

Cytokines/chemokines are involved in the immune response of infections, including HIV-1. We defined the profile of 48 cytokines/chemokines in cerebrospinal fluid from 18 cART patients with chronic HIV-1 infection by Luminex technology. Nine patients were affected with leukoencephalopathies: five with John Cunningham virus (JCV) + progressive multifocal leukoencephalopathy (PML) and four with JCV-not determined leukoencephalopathy (NDLE). In addition, nine HIV-1-positive patients with no neurological signs (NND) and five HIV-1-negative patients affected with acute disseminated encephalomyelitis (ADEM) were enrolled. Ten cytokines (IL-15, IL-3, IL-16, IL-18, CTACK, GRO1, SCF, MCP-1, MIF, SDF) were highly expressed in HIV-1-positive patients while IL-1Ra and IL-17 were present at a lower level. In addition, the levels of IL-17, IL-9, FGF-basic, MIP-1β, and MCP-1 were significantly higher (p < 0.05) in patients with neurological diseases (PML, NDLE, ADEM) with respect to NND. Focusing the attention to the cytokine profile in JCV + PML patients with respect to JCV-NDLE patients, only TNF-β was significantly downregulated (p < 0.05) in JCV + PML patients. This pilot study emphasized the role of immunoregulation in HIV-1-related neurological disorders during cART treatment
English
cART; Cytokines; HIV-1; Leukoencephalopathies
Settore MED/07 - Microbiologia e Microbiologia Clinica
Articolo
Esperti anonimi
2012
18
5
412
422
Pubblicato
Periodico con rilevanza internazionale
info:eu-repo/semantics/article
Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders / V. ZANIN, S. DELBUE, A. MARCUZZI, E. TAVAZZI, R. DEL SAVIO, S. CROVELLA, E. MARCHIONI, P. FERRANTE, M. COMAR. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - 18:5(2012), pp. 412-422. [10.1007/s13365-012-0109-y]
none
Prodotti della ricerca::01 - Articolo su periodico
9
262
Article (author)
no
V. Zanin, S. Delbue, A. Marcuzzi, E. Tavazzi, R. DEL SAVIO, S. Crovella, E. Marchioni, P. Ferrante, M. Comar
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/208219
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