Cryoglobulins may produce interference in results from electronic particle counters. Depending on their size, cold-precipitable globulin crystals can be counted as leucocytes and/or platelets. The Coulter Counter model S-Plus IV/D permits detection of this interference and its associated spurious counts by producing a characteristic WBC histogram accompanied by a leucocyte 'flag'. Using this instrument over a 1-year period, 10 cases of cryoglobulinaemia were detected, four from patients with lymphoproliferative disease and one from a patient with autoimmune disease. The remaining five were classified as essential mixed cryoglobulinaemia. The reproducibility of this instrument anomaly permits identification of the presence of cryoglobulins.
|Titolo:||Detection of cryoglobulins by Coulter Counter model S-Plus IV/D|
BANFI, GIUSEPPE (Primo)
|Parole Chiave:||Hematologic Tests ; Humans ; Cryoglobulinemia ; Middle Aged ; Cryoglobulins ; Leukocyte Count ; Female ; Platelet Count|
|Settore Scientifico Disciplinare:||Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica|
|Data di pubblicazione:||1988|
|Digital Object Identifier (DOI):||10.1111/j.1365-2257.1988.tb01194.x|
|Appare nelle tipologie:||01 - Articolo su periodico|