With the aim of evaluating the specific pattern of in vitro antibody production (IVAP) in human immunodeficiency virus type 1 (HIV-1)-infected long-term non-progressors (LTNPs), we tested 20 subjects who had remained asymptomatic for more than 8 years with a CD4+ cell count higher than 500/microliter and 59 patients at different stages of HIV-1 infection as controls. In cell cultures, IVAP was detected in 14 out of 20 LTNPs (70%), in 5 out of 6 recent seroconverters (83%), and in all the other control patients. Anti-p24 antibody production was significantly lower in LTNPs than in asymptomatic patients with a more recent infection. Recent seroconverters and patients with AIDS did not produce anti-p24 antibodies (P = 0.02). Anti-gp160 antibodies were produced by peripheral blood mononuclear cells from LTNPs in 12/20 cases. CD4+ cell count was significantly higher in IVAP-negative than in IVAP-positive LTNPs (P = 0.013), while the viral load was not significantly different. Specific anti-HIV-1 antibody production did not seem to be a correlate of long-term nonprogression.
Patterns of in vitro anti-human immunodeficiency virus type 1 antibody production in long-term nonprogressors / S. Rusconi, A. Berlusconi, L. Papagno, M.C. Colombo, C. De Maddalena, A. Riva, P. Bagnarelli, C. Balotta, M. Galli. - In: CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY. - ISSN 0090-1229. - 85:3(1997 Dec), pp. 320-323.
|Titolo:||Patterns of in vitro anti-human immunodeficiency virus type 1 antibody production in long-term nonprogressors|
RUSCONI, STEFANO (Primo)
BALOTTA, CLAUDIA (Penultimo)
GALLI, MASSIMO (Ultimo)
|Parole Chiave:||Anti-p24; HIV-1; IVAP|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||dic-1997|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1006/clin.1997.4470|
|Appare nelle tipologie:||01 - Articolo su periodico|