The aim of our study was to investigate the possible correlation of in vitro antibody production (IVAP) directed to the gp160 protein of HIV-1 with CD4(+) slopes, plasma viremia, and disease progression in long-term nonprogressors (LTNPs). Nineteen subjects with a long-term nonprogressive HIV-1 infection were studied and followed for 2 years, During the follow-up, in vitro anti-gp160 producers showed negative CD4(+) slopes in the majority of cases (9 of 12), whereas 5 of 7 nonproducers showed positive CD4(+) slopes. Plasma viremia values, which were not significantly different in the two groups at baseline, became significantly higher in anti-gp160 producers when compared with nonproducers during the follow-up (p = 0.012). Finally, a trend toward progression was observed in the group of producers but not in nonproducers, These findings suggest that the in vitro production of anti-gp160 antibodies by peripheral B cells is not a correlate of protection, and may represent an early predictor of progression in LTNPs.

Lack of in vitro anti-gp160 antibody production is a correlate of nonprogression among HIV type 1-infected individuals / S. Rusconi, S. Santambrogio, A. Di Marco, M. Colombo, P.M. Citterio, F. Adorni, M. Galli. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 14:15(1998 Oct 10), pp. 1341-1343.

Lack of in vitro anti-gp160 antibody production is a correlate of nonprogression among HIV type 1-infected individuals

S. Rusconi
Primo
;
P.M. Citterio;M. Galli
Ultimo
1998-10-10

Abstract

The aim of our study was to investigate the possible correlation of in vitro antibody production (IVAP) directed to the gp160 protein of HIV-1 with CD4(+) slopes, plasma viremia, and disease progression in long-term nonprogressors (LTNPs). Nineteen subjects with a long-term nonprogressive HIV-1 infection were studied and followed for 2 years, During the follow-up, in vitro anti-gp160 producers showed negative CD4(+) slopes in the majority of cases (9 of 12), whereas 5 of 7 nonproducers showed positive CD4(+) slopes. Plasma viremia values, which were not significantly different in the two groups at baseline, became significantly higher in anti-gp160 producers when compared with nonproducers during the follow-up (p = 0.012). Finally, a trend toward progression was observed in the group of producers but not in nonproducers, These findings suggest that the in vitro production of anti-gp160 antibodies by peripheral B cells is not a correlate of protection, and may represent an early predictor of progression in LTNPs.
Settore MED/17 - Malattie Infettive
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/207324
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact