The aim of our study was to investigate the possible correlation of in vitro antibody production (IVAP) directed to the gp160 protein of HIV-1 with CD4(+) slopes, plasma viremia, and disease progression in long-term nonprogressors (LTNPs). Nineteen subjects with a long-term nonprogressive HIV-1 infection were studied and followed for 2 years, During the follow-up, in vitro anti-gp160 producers showed negative CD4(+) slopes in the majority of cases (9 of 12), whereas 5 of 7 nonproducers showed positive CD4(+) slopes. Plasma viremia values, which were not significantly different in the two groups at baseline, became significantly higher in anti-gp160 producers when compared with nonproducers during the follow-up (p = 0.012). Finally, a trend toward progression was observed in the group of producers but not in nonproducers, These findings suggest that the in vitro production of anti-gp160 antibodies by peripheral B cells is not a correlate of protection, and may represent an early predictor of progression in LTNPs.
|Titolo:||Lack of in vitro anti-gp160 antibody production is a correlate of nonprogression among HIV type 1-infected individuals|
RUSCONI, STEFANO (Primo)
GALLI, MASSIMO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||10-ott-1998|
|Digital Object Identifier (DOI):||10.1089/aid.1998.14.1341|
|Appare nelle tipologie:||01 - Articolo su periodico|