The 'in vitro' effect of flunoxaprofen on human polymorphonuclear leukocyte (PMN) activities has been studied. Preincubation of PMN for 30 minutes at 37°C with flunoxaprofen inhibited their leucoattractant-induced migration in a dose-dependent fashion. The basal level of PMN oxidative metabolism, measured by chemiluminescence, was increased after preincubation with the drug; however, flunoxaprofen, in the same conditions, was able to inhibit the chemiluminescent response of zymosan-stimulated PMN. No significant effect on PMN phagocytic activity was found. These data indicate that the nonsteroidal anti-inflammatory drug flunoxaprofen may have direct effects on neutrophil migration and activation and suggest that the anti-inflammatory effects of the drug may be related, at least in part, to its direct action on neutrophil responses.
Effect of flunoxaprofen on human phagocytic cell function / F. Capsoni, E. Venegoni, F. Minonzio, A. Forgione, A. Zanoboni, C. Zanussi. - In: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. - ISSN 0011-393X. - 39:1(1986), pp. 75-81.
Effect of flunoxaprofen on human phagocytic cell function
F. CapsoniPrimo
;
1986
Abstract
The 'in vitro' effect of flunoxaprofen on human polymorphonuclear leukocyte (PMN) activities has been studied. Preincubation of PMN for 30 minutes at 37°C with flunoxaprofen inhibited their leucoattractant-induced migration in a dose-dependent fashion. The basal level of PMN oxidative metabolism, measured by chemiluminescence, was increased after preincubation with the drug; however, flunoxaprofen, in the same conditions, was able to inhibit the chemiluminescent response of zymosan-stimulated PMN. No significant effect on PMN phagocytic activity was found. These data indicate that the nonsteroidal anti-inflammatory drug flunoxaprofen may have direct effects on neutrophil migration and activation and suggest that the anti-inflammatory effects of the drug may be related, at least in part, to its direct action on neutrophil responses.Pubblicazioni consigliate
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