Objective: To analyze in the real life clinical setting the effect of fluorchinolones treatment in the management of elevated (4-10 ng/ml) prostate-specific antigen level we conducted an observational prospective cohort study. Material and methods: Eligible for the study were subjects aged 45-75 years with a PSA level 4-10 ng/ml, consecutively observed during their routine practice by first level outpatients urologic centres. Results: A total of 740 patients, mean value of total PSA at study entry: 5.8 (SD = 1.6)) entered the study. A total of 616 subjects were treated with ciprofloxacin. The mean serum t-PSA value decreased between study entry and final visit of 1.31 ng/ml (SD 4.19) (p < 0.05). At follow up visit the 49.4% (95% CI 44.1-55.5) of patients had PSA level < 4 ng/ml. in comparison with patients with t-PSA < = 5.0 ng/ml, the OR of having normal t-PSA value at follow up were respectively 0.61 (95%CI 0.4-0.9) and 0.23 (0.1-0.3) for patients with t-PSA 5.1-6.2 and ≥ 6.3, in comparison with those with t-PSA < = 5.0. Conclusion: The results of this large observational prospective study showed that a 2-3 week course of treatment with ciprofloxacin 1000 mg is able to significantly reduce the PSA level in about 50% of men aged 45-75 years with t-PSA levels of 4-10 ng/ml.

A prospective observational cohort study on patients with PSA levels ranging from 4 to 10 ng/ml at opportunistic screening : management and responses to ciprofloxacin 1000 mg / P. Verze, F. Parazzini, D. Arcaniolo, S. Cipriani, V. Mirone. - In: ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA. - ISSN 1124-3562. - 84:2(2012 Jun), pp. 89-93.

A prospective observational cohort study on patients with PSA levels ranging from 4 to 10 ng/ml at opportunistic screening : management and responses to ciprofloxacin 1000 mg

F. Parazzini;
2012-06

Abstract

Objective: To analyze in the real life clinical setting the effect of fluorchinolones treatment in the management of elevated (4-10 ng/ml) prostate-specific antigen level we conducted an observational prospective cohort study. Material and methods: Eligible for the study were subjects aged 45-75 years with a PSA level 4-10 ng/ml, consecutively observed during their routine practice by first level outpatients urologic centres. Results: A total of 740 patients, mean value of total PSA at study entry: 5.8 (SD = 1.6)) entered the study. A total of 616 subjects were treated with ciprofloxacin. The mean serum t-PSA value decreased between study entry and final visit of 1.31 ng/ml (SD 4.19) (p < 0.05). At follow up visit the 49.4% (95% CI 44.1-55.5) of patients had PSA level < 4 ng/ml. in comparison with patients with t-PSA < = 5.0 ng/ml, the OR of having normal t-PSA value at follow up were respectively 0.61 (95%CI 0.4-0.9) and 0.23 (0.1-0.3) for patients with t-PSA 5.1-6.2 and ≥ 6.3, in comparison with those with t-PSA < = 5.0. Conclusion: The results of this large observational prospective study showed that a 2-3 week course of treatment with ciprofloxacin 1000 mg is able to significantly reduce the PSA level in about 50% of men aged 45-75 years with t-PSA levels of 4-10 ng/ml.
Antimicrobial treatment; Prospective study; PSA level
Settore MED/40 - Ginecologia e Ostetricia
ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/207119
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