Background: Despite its frequency, there is a paucity of data on risk factors for basal cell carcinoma. Objective: We assessed potential risk factors for basal cell carcinoma in a population from southern Europe. Methods: This multicenter case-control study involved 528 newly diagnosed cases and 512 controls. Results: In the multivariate analysis, red hair, lighter colored eyes, high nevus counts on the upper limbs, and the presence of solar lentigines and actinic keratoses were all associated with basal cell carcinoma. The risk of the tumor increased in subjects who reported burning easily and experiencing sunburn episodes before 15 years of age. An association was documented with indices of recreational sun exposure but no clear evidence of exposure-effect relationship was found. No relation was found with occupational sun exposure. Finally, basal cell carcinoma appeared to be significantly associated with a family history of skin tumors, a personal history of tumors other than those on skin, and radiotherapy. Conclusion: Genetic and environmental factors appear to be involved in the onset of basal cell carcinoma.

Host-related and environmental risk factors for cutaneous basal cell carcinoma: evidence from an Italian case-control study / L. Naldi, A. DiLandro, B. D'Avanzo, F. Parazzini. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 42:3(2000 Mar), pp. 446-452.

Host-related and environmental risk factors for cutaneous basal cell carcinoma: evidence from an Italian case-control study

F. Parazzini
Ultimo
2000

Abstract

Background: Despite its frequency, there is a paucity of data on risk factors for basal cell carcinoma. Objective: We assessed potential risk factors for basal cell carcinoma in a population from southern Europe. Methods: This multicenter case-control study involved 528 newly diagnosed cases and 512 controls. Results: In the multivariate analysis, red hair, lighter colored eyes, high nevus counts on the upper limbs, and the presence of solar lentigines and actinic keratoses were all associated with basal cell carcinoma. The risk of the tumor increased in subjects who reported burning easily and experiencing sunburn episodes before 15 years of age. An association was documented with indices of recreational sun exposure but no clear evidence of exposure-effect relationship was found. No relation was found with occupational sun exposure. Finally, basal cell carcinoma appeared to be significantly associated with a family history of skin tumors, a personal history of tumors other than those on skin, and radiotherapy. Conclusion: Genetic and environmental factors appear to be involved in the onset of basal cell carcinoma.
Questionnaires ; Humans ; Aged ; Carcinoma, Basal Cell ; Skin Neoplasms ; Italy ; Multivariate Analysis ; Sunburn ; Risk Factors ; Adult ; Case-Control Studies ; Environmental Exposure ; Middle Aged ; Genetic Predisposition to Disease ; Female ; Male
Settore MED/40 - Ginecologia e Ostetricia
mar-2000
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/206624
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