Objective: To evaluate the effects of two types of hormone replacement therapy, an estrogen-progestin combination and tibolone, on uterine myomas in menopausal women. Study design: Thirty-eight menopausal women with one or more uterine myomas were randomized to treatment with a transdermal system continuously releasing estradiol 50 mu g/day combined with oral medroxyprogesterone acetate (MPA) 10 mg/day for 12 days/month or tibolone tablets 2.5 mg/day. The scheduled duration of both treatments was 12 months. Physical examination and abdominal/transvaginal ultrasonography were performed before entering the study and at 3, 6 and 12 months of treatment. At each ultrasonography the overall uterine volume was determined as well as the size of each myoma and the endometrial thickness and characteristics. Results: No statistically significant difference was detected between the two groups at any time during treatment. However, within-group analysis showed a significant increase of uterine volume and of myoma number and size in the estrogen-progestin group, whereas no such increase occurred in the patients treated with tibulone. Also, the mean endometrium width increased significantly from baseline to the end of treatment in the estrogen-progestin group, but not in the tibulone group. Conclusions: Tibolone seems a valid alternative in menopausal patients with uterine myomas as it provides adequate relief from menopausal symptoms and avoids volume increase of the uterus and myomas.
A randomized study of the effects of tibolone and transdermal estrogen replacement therapy in postmenopausal women with uterine myomas / L. Fedele, S. Bianchi, R. Raffaelli, G. Zanconato. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 88:1(2000 Jan), pp. 91-94.
|Titolo:||A randomized study of the effects of tibolone and transdermal estrogen replacement therapy in postmenopausal women with uterine myomas|
FEDELE, LUIGI (Primo)
BIANCHI, STEFANO (Secondo)
|Parole Chiave:||Hormone replacement therapy; Menopause; Tibolone; Uterine myomas|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||gen-2000|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0301-2115(99)00115-3|
|Appare nelle tipologie:||01 - Articolo su periodico|