Approximately 20 years after the Seveso accident, we designed a case-control study on 101 subjects who developed chloracne after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 211 controls from the same area, to establish the dose-exposure relation and to identify dioxin susceptibility factors. Subjects with elevated plasma TCDD levels (>10 pg/g fat) showed an almost 4 times higher risk of developing chloracne. Chloracne risk was higher in subjects with high TCDD plasma levels, young people (≤8 years) and/or those with fair hair. The health status of chloracne cases twenty years after the accident was not different from that of control subjects.
Suscettibilità a diossina in soggetti cloracneici della popolazione di Seveso / M. Bonzini, A. Baccarelli, A. Pesatori, D. Consonni, D. Patterson J. r., M. Rubagotti, N.E. Caporaso, P.A. Bertazzi, M.T. Landi. - In: GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA. - ISSN 1592-7830. - 26:4 Suppl.(2004), pp. 27-29.
Suscettibilità a diossina in soggetti cloracneici della popolazione di Seveso
M. BonziniPrimo
;A. BaccarelliSecondo
;A. Pesatori;M. Rubagotti;P.A. BertazziPenultimo
;
2004
Abstract
Approximately 20 years after the Seveso accident, we designed a case-control study on 101 subjects who developed chloracne after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 211 controls from the same area, to establish the dose-exposure relation and to identify dioxin susceptibility factors. Subjects with elevated plasma TCDD levels (>10 pg/g fat) showed an almost 4 times higher risk of developing chloracne. Chloracne risk was higher in subjects with high TCDD plasma levels, young people (≤8 years) and/or those with fair hair. The health status of chloracne cases twenty years after the accident was not different from that of control subjects.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
